Biological physics

My biological physics is on the dynamics of proteins, RNA, etc, inside cells. I was co-chair of the CECAM workshop ‘The Self-Organised Cytoplasm‘ in July 2014 (report here).

Transport in cells

anderson_cell_schem

The complex viscous energy-consuming fluid inside cells is very far from uniform, and very far from thermodynamic equilibrium. In a Physical Review Letter (preprint on arXiv), I suggest that larger particles (about 100 nm across) inside cells may move around in cells at least partly by surfing these gradients. Motion of particles due to concentration gradient is called diffusiophoresis, which is quite topical at the moment.

Modelling diffusion inside cells of the protein whose absence causes Duchenne muscular dystrophy

I have collaborated with muscle cell biologists on modelling the dynamics of the protein Dystrophin inside live muscle cells. Dystrophin is a medically important protein, the absence of this protein causes the genetic disease Duchenne Muscular Dystrophy. This work was published in eLife in October 2015. This site hosts the app used there. There is a news release on this work.